High Kidney Donor Profile Index (KDPI)

When you’re on the waitlist for a kidney transplant, understanding the types of kidneys available can help you make informed decisions. You may already know about several types of kidneys that people with kidney failure can get today, including from a:

• Living donor, either someone you know, someone anonymous, or through a paired-exchange program
• Deceased donor

But you may not have heard about kidneys that are considered underutilized. There are not enough donor kidneys for all the people with kidney failure who need a kidney transplant – so you should know that an underutilized kidney may be a good option for you to consider.

Underutilized kidneys have something about the kidney or the donor that is less than perfect but can still work well. Saying “yes” to one of these kidneys can potentially improve your chances of getting a kidney sooner and may be a better choice than staying on dialysis. You will need to provide written consent to the transplant center if you would like to consider these kidneys, and you can change your mind at any time – so ask a lot of questions and keep talking to your healthcare team even after you have been added to the transplant waitlist.

There are two main kinds of underutilized kidneys:

• High Kidney Donor Profile Index (KDPI)
• Increase Risk of Disease (IRD) Kidneys.

Both types can be good options for some patients and may be a better choice than staying on long-term dialysis or waiting a long time on the waitlist.

While high KDPI or IRD kidneys might not be your first choice, accepting them for your transplant may offer some important benefits, including:

1.You may be able to get a kidney transplant faster.

2.For many people, these kidneys function very well for a long time.  

Let’s start with high KDPI kidneys by looking at how donor kidneys are categorized.

The Kidney Donor Profile Index (KDPI) is a scoring system that ranges from 0 to 100. This score, which is based on certain guidelines, rates how well a donor kidney is expected to work compared to the kidneys that were transplanted in the previous year. This score is based on several things that are known about the person who donated the kidney, like their age, height, weight, and health history. A lower KDPI score means that the donor kidney is expected to work longer (10-15 years), and a higher KDPI score means that the donor kidney is expected to work for a shorter time (7-10 years).

The KDPI score plays a key role in the kidney-matching process. Kidneys with a low KDPI score are usually given to people who are expected to live a long time with their new kidney. These patients often include younger people, people who have not had a transplant before, and those who have spent less time on dialysis.

One category of underutilized kidneys are those with a high KDPI score, which means the score is over 85. It is important to know that these kidneys are likely to function for many years and may be a good alternative to staying on dialysis for patients who are older, have been on dialysis a long time, or have other health concerns that make it harder to receive a kidney transplant.

Another category of underutilized kidneys is from donors who are at an increased risk of disease (IRD). This includes people who have died from drug overdoses, which is becoming more common due to the opioid crisis. These kidneys, like all kidneys, go through a lot of testing to make sure they’re safe enough to transplant. Also, every transplant team is required to talk to each patient about the possible risks of accepting these kidneys.

Over the years, research has shown that IRD kidneys have similarities to typical kidneys, including:

• IRD kidneys last a similar amount of time.
• IRD kidneys have about the same rate of delayed graft function, which is when a kidney transplant does not work right away
• IRD kidneys have about the same rate of rejection after transplantation
• Patients who get an IRD kidney live about the same amount of time
  • In one study, the 10-year survival rate was 72.7% for people who had a hepatitis C kidney transplant, compared to 76.5% who did not receive a hepatitis C kidney.

You may have concerns about the lifestyle of some IRD kidney donors, but research shows that kidneys from drug overdose donors can work just as well as kidneys from donors who died from other causes, such as accidents or violence.

While rare, viral infections like hepatitis C from an IRD kidney are possible. If you contract a disease like hepatitis C from an IRD kidney, it is highly treatable.